Connexins, gap junctions, and glia
نویسندگان
چکیده
منابع مشابه
Update on connexins and gap junctions in neurons and glia in the mammalian nervous system.
Among the 20 proposed members of the connexin family of proteins that form gap junctional intercellular communication (GJIC) channels in mammalian tissues, over half are reported to be expressed in the nervous system. There have been conflicting observations, however, concerning the particular connexins expressed by astrocytes, oligodendrocytes, Schwann cells and neurons. Identification of the ...
متن کاملDegradation of connexins and gap junctions.
Connexin proteins are short-lived within the cell, whether present in the secretory pathway or in gap junction plaques. Their levels can be modulated by their rate of degradation. Connexins, at different stages of assembly, are degraded through the proteasomal, endo-/lysosomal, and phago-/lysosomal pathways. In this review, we summarize the current knowledge about connexin and gap junction degr...
متن کاملConnexins, gap junctions and tissue invasion.
Formation of metastases negatively impacts the survival prognosis of cancer patients. Globally, if the various steps involved in their formation are relatively well identified, the molecular mechanisms responsible for the emergence of invasive cancer cells are still incompletely resolved. Elucidating what are the mechanisms that allow cancer cells to evade from the tumor is a crucial point sinc...
متن کاملRoles of gap junctions, connexins, and pannexins in epilepsy
Enhanced gap junctional communication (GJC) between neurons is considered a major factor underlying the neuronal synchrony driving seizure activity. In addition, the hippocampal sharp wave ripple complexes, associated with learning and seizures, are diminished by GJC blocking agents. Although gap junctional blocking drugs inhibit experimental seizures, they all have other non-specific actions. ...
متن کاملGap junctions and connexins: potential contributors to the immunological synapse.
Gap junctional communication is a widespread mechanism for metabolic coupling of adjoining cells. In the immune system, evidence has built up showing that lymphocytes possess the protein building blocks of gap junctions, the connexins. The most widespread is connexin 43, but connexin 40 is also present in secondary lymphoid organs. Inhibitors of gap junctional communication, especially the high...
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ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: Membrane Transport and Signaling
سال: 2013
ISSN: 2190-460X
DOI: 10.1002/wmts.87